Adenosine Receptor A2b

        The A2bAR has been  cloned from both rat and human libraries and expressed in a variety of cells (Olah and Stiles, 1995). The A2b receptor is much smaller than the A2a receptor and is much more similar in size to the A1ARs and A3ARs. Studies on the A2b receptor have been few in number, by and large due to the fact that there are no useful radioligands, either agonists or antagonist, available to study this interesting receptor. The only radioligand that has had some use is [³H]NECA and its relatively low affinity precludes detailed studies. The human A2b adenosine receptor was first cloned from a hippocampal cDNA library in 1992 (Pierce et al., 1992). This receptor is a G protein-coupled receptor with 45% homology to the human A1 and A2b receptors. Upon activation, this receptor stimulates intracellular cAMP formation.

Databases of A2b  Adenosine Receptor